So Long, And Thanks For All The Rides

…and, two weeks in, somebody has stolen my scooter.

They came into the complex between 7am and 8am and broke the supposedly “unbreakable” combination lock and walked off with it. I know it was between 7 and 8 because I’m working on a project and I went to bed around 7; the maintainence guy told me he came on at 8 and it was gone.

I can’t fucking win, can I?

RIP Bernie Mac

Goddamn, that’s a shame. Bernie Mac was a funny, funny motherfucker. His performance in Bad Santa alone is the stuff of comedy legend. Even in small roles — like Friday or even Transformers — he stood out.

Cheers, baby. Thanks for the funny.

Why We're All Going To Die Next Tuesday

In the past, large pharmaceutical companies were the primary sources of antibiotic research. But many of these companies have abandoned the field. “Eli Lilly and Company developed the first cephalosporins,” Moellering told me, referring to familiar drugs like Keflex. “They developed a huge number of important anti-microbial agents. They had incredible chemistry and incredible research facilities, and, unfortunately, they have completely pulled out of it now. After Squibb merged with Bristol-Myers, they closed their antibacterial program,” he said, as did Abbott, which developed key agents in the past treatment of gram-negative bacteria. A recent assessment of progress in the field, from U.C.L.A., concluded, “FDA approval of new antibacterial agents decreased by 56 per cent over the past 20 years (1998-2002 vs. 1983-1987),” noting that, in the researchers’ projection of future development only six of the five hundred and six drugs currently being developed were new antibacterial agents. Drug companies are looking for blockbuster therapies that must be taken daily for decades, drugs like Lipitor, for high cholesterol, or Zyprexa, for psychiatric disorders, used by millions of people and generating many billions of dollars each year. Antibiotics are used to treat infections, and are therefore prescribed only for days or weeks. (The exception is the use of antibiotics in livestock, which is both a profit-driver and a potential cause of antibiotic resistance.)

From “Superbugs”, a rather scary article in The New Yorker.

63 Years

63 years ago today, a fellow named Paul Tibbets flew a plane named after his mother halfway around the world and dropped the first atomic bomb on the Japanese city of Hiroshima.

If you want to know how this came to be, may I recommend my micropatronage-funded essay “Dark Miracle“? It’s about the Manhattan Project and Trinity, the test site where the first bomb was tested, a few days before Tibbets dropped his own version. I like the piece more the more often I read it; I hope you will, too.